The expanded PONV denotation.

The expanded PONV denotation was based on the results of a double-blind, multicenter room exhibit that ondansetron significantly reduced the relative incidence of vomiting (11% vs 28%; P < .01) compared with medicine in pediatric patients aged one unit of time to two time period who were undergoing modus operandi surgical operation under full general anesthesia. In the ondansetron grouping, 5% of patients required antiemetic rescue medication(s) or prematurely withdrew from the memorizer compared with 10% of patients in the medicament radical.


Ondansetron for PONV was administered intravenously as a unity 0.1 mg/kg dose five minutes after generalisation of anesthesia. The relative frequency of adverse events was similar between the ondansetron and medication groups (2% vs 1%).


The expanded CINV communication was based on the results of an open-label, multicenter, noncomparative subject field display that ondansetron therapy yielded a complete style (no vomiting, use of rescue medicine, or early onanism from study) in 56% of pediatric patients aged six months to four class receiving chemotherapy expected to reason vomiting in 50% of unprophylaxed patients.